I am only five years late on this thread, but also use R1C1 for everything. It is just so much more powerful and more intuitive - I mean it is a coordinate system after all. A1 is ok for small uncomplicated things, but if you have a lot of data columns and rows, R1C1 just shines. Firstly, the formulas never change in a column. It its just so much easier to debug complex spreadsheets. Secondly referring to column CF is totally counter intuitive, C84 if much more intuitive at face value. I also often use absolute references unless I specifically need to have a relative reference. This keeps formulas short and easy to read. I think it is simply a much, much better and more sustainable practice to use R1C1 all the way. I have been programming with Excel from pre VBA days.