Richard, a couple more thoughts on Filemaker:
It's quite a different interface, so databases produced in FM have a very different look and feel.
The learning curve isn't as steep to get going.
You can create PDF attachments from any report and email them straight out of FileMaker. No hassles with Outlook getting narky.
I haven't had the chance to give it a go, but the reported file capacity in version 8 and higher is about 4 terabytes. Compare that to 2 gigabytes for Access, and that's a pretty serious difference.
As for connectivity, FM uses ODBC and JDBC, but not ADO, which is MS-only. In a Microsoft environment I found that to be a bit of a disadvantage.
Some things that Access does out of the box -- events, exporting data to files whose name you change on the fly -- don't ship natively in FM, but you can get them as plug-ins and they work very well.
If you're looking to Web-enable a database, I reckon FM is better. You can do it natively using a special version of FM Server, and a very high proportion of your page layout and scripting translates directly to the browser. Again, later versions are better.
If you are hosting a workgroup database and don't want or need to go all the way to the big guys, FM Server lets you simultaneously handle 255 connections. Access doesn't do that -- at least not that I've seen. It also works over Citrix.
Can't think of anything else at the moment, but that might be food for thought.
Denis
I'll stop hijacking this thread now 
