If you are creating a formula and you are selecting upwards, you can do what you were doing already, but with a different direction: CTRL + SHIFT + UP ARROW.
If you have a lot of blanks and know you want to head straight to the top* of the worksheet, press CTRL + SHIFT + HOME (takes you to A1*), then while holding SHIFT, use your arrow key to move the selection back to the single column you started from.
*Takes you to A1 if you don't have any frozen panes (View > Freeze Panes)