"If you maximize the excel window then save - what happens? " >> I already answered that. See above "Doesn't matter whether max/min before or after." "Are you sure you started Excel in safe mode? " >> Yes, I'm sure. See a previous answer where I answered that: "Excel "on the move" No. I went to that link, and tried the safe mode start for Excel. The problem was unaffected. Every excel file I save (with or without changes) moves to another location on screen after close. No other files behave this way. " So that didn't make a difference. Incidentally, holding down the shortcut key and opening any excel doesn't give me a safe mode prompt for any excel file. ****In the end, it's any excel file on my desktop, on save, with or without changes, and unrelated to minimize/maximize before or after save, moves to upper left of my screen on close.**** Remain open to solutions.