Thanks for the response.
I'm using Excel 2007, but saving the file in the 97-2003 .xls format.
This has happened before, but the program is not crashing. I'm doing a clean save, close and reopen. I do have autosave on, set at every 2 minutes.
The #N/A replaces almost every IRR function in the workbook, plus others in a seemingly random way.