If you are editing Threaded Comments frequently enough to need a shortcut key, I suspect you should be Notes and not Comments.
As I said in the previous post, I think editing anything other than the very latest post is potentially really misleading.
You can possibly set up a macro and assign a shortcut key to that but you would have to tell it which message in the chain you want to want to edit.
That is probably why Ctrl+Shift+F2 can't take you straight to edit mode since it takes you to the point at which you need to either reply OR to "select which message" you want to edit.
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