I interpreted what northguy wants a little differently: hide the unused columns to the right.
Select the first column you do not want to see. Press Ctrl+Shift+RightArrow. That should take you to column XFD. Then hide the selected columns. I would use the right-click context menu and select "Hide" to do this. This will hide the column labels, too
You can do the same thing with rows.
I interpreted what northguy wants a little differently: hide the unused columns to the right.
Select the first column you do not want to see. Press Ctrl+Shift+RightArrow. That should take you to column XFD. Then hide the selected columns. I would use the right-click context menu and select "Hide" to do this. This will hide the column labels, too
You can do the same thing with rows.