Can you provide more details on your request, such as:Can you give more details about using VBA? Since I'm not familiar with that.
Private Sub Workbook_BeforeSave(ByVal SaveAsUI As Boolean, Cancel As Boolean)
If Sheets("Request Form").Range("B15") <> "" And Sheets("Request Form").Range("E19") = "" Then
Cancel = True
MsgBox "You must populate cell E19 before saving and try again!", vbOKOnly, "ERROR!"
End If
End Sub