We have an Excel sheet that we've been using for over a decade to generate programs for us. Suddenly on Monday the two buttons to initialize and serialize on the sheet became inactive. The cursor does change to an arrow when move over the buttons, but the buttons do not depress and there is not reaction to clicking on them. I set the Macro Security level to low and set ActiveX controls to enable everything. The curious thing is that it suddenly stopped working for 3 of the 4 user profiles on the computer. So, yes, under one user profile, everything still works (same sheet, same macros). So, I'm trying to figure out if there is something that I'm missing. The sheet was working fine until Monday. I'm not aware of any updates or other activities that may have corrupted anything, evenso, the fact that it still works on one user profile is perplexing to me. I tried installing everything on another computer, but ran into the same issue, oddly enough.