Joe will do but I think I found out the issue. I used the query wizard (below) to build a mismatch query, the query takes about to minute to calculate. I will go back and index the original table to see if it will help with performance.
SELECT [PBUSE CPL Q (SRRC)].LIN, [PBUSE CPL Q (SRRC)].SUBLIN, [PBUSE CPL Q (SRRC)].NSN, [PBUSE CPL Q (SRRC)].[NSN Nomenclature], [PBUSE CPL Q (SRRC)].PBIC, [PBUSE CPL Q (SRRC)].UIC, [PBUSE CPL Q (SRRC)].[SER|DETECT SN|REG|LOT|SYS NO]
FROM [PBUSE CPL Q (SRRC)] LEFT JOIN [MAT_SIT SN Q (SRRC)] ON ([PBUSE CPL Q (SRRC)].UIC = [MAT_SIT SN Q (SRRC)].UIC_HELP) AND ([PBUSE CPL Q (SRRC)].[SER NO] = [MAT_SIT SN Q (SRRC)].[SER NO])
WHERE ((([MAT_SIT SN Q (SRRC)].[SER NO]) Is Null))
ORDER BY [PBUSE CPL Q (SRRC)].LIN, [PBUSE CPL Q (SRRC)].UIC;