That would mean what, I choose list item 1 in the combo and textboxes 2 and 3 are disabled? Choose combo list item 2 and other textboxes are disabled? And those that were disabled no longer should be when another option is chosen? Or they remain disabled?
To answer simply and based on my interpretation of your question, you would use the AfterUpdate event of the combo and act according to what you want. However, I don't know what a combobox "option button" is. There are also controls called option buttons but I suspect those are not involved here.