Yes. one of the big differences between the two is how they handle data. In Access (and other relational database programs), the order of the data within the table really has no meaning/bearing (someone one described it as a "bag of marbles", with all the records mixed in in no particular order). This can make things like cumulative ordering and comparing to previous record (order-wise) a bit challenging. Sometimes, I use VBA to order the records in a DAO Recordset, and iterate through them.
Things like "lookups" are actually much easier to do in Access then they are in Excel, by nature of being a "relational" database. Instead of having to do VLOOKUP or INDEX/MATCH formulas, you simply join two tables on common field(s).
The most important thing when using Access is to design your data tables in a manner which will allow you to complete most tasks without too much additional effort. Table Design is EXTREMELY important. There are "Rules of Normalization" which should be followed (you can Google that term). Two keys are:
1. You should NOT have multiple tables with the same structure. If you do, they should probably be one table, maybe adding another "identifying" field if you need to differentiate them (i.e. you would have different tables for different years data, you would simply have one table with a year field - you can filter them out using Queries).
2. Queries are where most of your work happens, filters, calculations, grouping, etc.
I hope this help gives you a start. It is important to design it right, or you will have a difficult time. It happened to me the first time I built an Access database!